Who Is PharmaCare? PharmaCare is the leading specialized pharmacy providing care to thousands of individuals across the country living with challenging health conditions. We assist people with the emotional and physical demands of taking highly intensive therapies with knowledge, compassion, and individualized care. We offer the convenience of both home-delivery and walk-in service via a growing network of neighborhood locations. What Makes PharmaCare a Specialty Pharmacy? PharmaCare provides comprehensive pharmacy care to individuals on maintenance medications and other complex medication regimens. Our pharmacists are specially trained in high-risk conditions and highly skilled at helping you manage complex medication therapies. In addition, we offer a variety of advanced services such as medication adherence monitoring, expert medication counseling, and drug interaction monitoring. Is PharmaCare Right for Me? Each PharmaCare location is an important part of its community and we welcome all our neighbors to take advantage of our services. Our neighborhood pharmacies are especially valuable to those in the community who require the extra level of care provided by a specialty pharmacy. If you are not located near one of our neighborhood locations, or you prefer the added privacy and convenience of home-delivery, then one of our national home-delivery pharmacy programs may be right for you. In general, if you are receiving a complex medication regimen or require multiple maintenance medications, PharmaCare could be a valuable member of your health care team. For more information call us today at 1-800-238-7828 or complete our special questionnaire: Is PharmaCare right for me? Remember, while PharmaCare is able to serve most individuals living with a chronic health condition, you can learn more about what we can do for you by calling 1-800-238-7828. You may also stop by the PharmaCare location nearest you! Your Local PharmaCare Pharmacy Each PharmaCare location is a full-service pharmacy offering specialized pharmacy care designed to meet the challenging demands of your condition. We understand the value of building a 1 to 1 relationship with a local pharmacist who understands you and your needs. We continuously educate our pharmacists so that they can play an active role in your therapy and provide the information and support you expect. Each PharmaCare location is more than just a highly specialized pharmacy, it's a vital part of your community. Everything you need to help you feel your best PharmaCare is a full-service pharmacy with expert pharmacists offering specialized care designed to meet the specific demands of your condition. As America's largest specialty pharmacy, all of the following services are provided to PharmaCare clients at no additional charge : Hard To Find Medications. PharmaCare locations stock many hard to find medications and our pharmacists are familiar with their administration and side effects. A Full-Line of Complementary Products. In addition to prescription medications each location stocks a diverse supply of vitamins, supplements and nutritionals. Our pharmacists can assist you with selections and provide counseling on their use. 24-Hour Medication Counseling By Phone. Our pharmacists are available 7 days a week 24 hours a day to answer your questions. Drug Interaction and Compliance Monitoring. PharmaCare pharmacists provide individual support and guidance to help make it easier to take your medications as prescribed. Reimbursement Counseling. PharmaCare works with over 11,000 insurance plans, drug cards, Medicare, Medicaid, and AIDS drug assistance programs. Local Delivery Service. You have the option of having your medication delivered each month, when appropriate, making refills hassle-free. PharmaCare can provide you with a 30, 60, or 90 day supply of medications (as your coverage allows). Patient Education Materials. We are committed to helping you stay healthy. We regularly provide our exclusive wellness materials including and magazines. Support. In addition to medication counseling, we help you address financial and emotional issues, and to help identify tools to help you better cope with your condition. You will also benefit from the resources made available to you through this web site, including: timely news and clinical updates, selected articles from our LifeTIMES magazines, resource directories, and other wellness materials. As a pharmacy that specializes in chronic conditions, our web site offers visitors several disease-specific wellness centers with valuable online resources. To learn more about our specialized pharmacy services, visit the location nearest you, request a Free Information Kit, or call us today at 1-800-238-7828. Revised recognition process for overseas trained pharmacists The Council of Pharmacy Registering Authorities and the Australian Pharmacy Examining Council (APEC) have announced a revised recognition process for overseas trained pharmacists seeking registration in Australia. From 1 December 2006, all overseas trained pharmacists, irrespective of their country of origin, will be required to be assessed for competency to practise in Australia by undertaking a formal APEC process. A modified process will be introduced for eligible holders of qualifications from the UK, Ireland, USA and Canada. This will be a shortened process which will require passing a new examination known as Competency Assessment of Overseas Pharmacists (CAOP). CAOP will be offered four times a year in Australia and overseas. Succesfull applicants will be eligible for registration after they have satisfactorily completed a minimum period of four weeks supervised practice in Australia and have satisfied an assessment by the state registering authority. This will include a national examination of pharmacy law and ethics. Pharmacists from other countries will continue to be assessed by the current process, which includes formal examination, longer periods of supervised pratice and a final assessment of competency. New Zealand pharmacists will continue to be exempt from APEC requirements. New Zealand's educational qualifications are closely linked to Australia's through shared accreditation requirements and practice standards are similar. Michigan Board of Pharmacy Welcome to the Michigan Board of Pharmacy web site! Our goal is to provide up-to-date information on various topics related to the practice of pharmacy in Michigan. We hope you find this information helpful and invite you to check out our web site often. > More Licensing Information • Pharmacy 2006 Approved CE Programs • Pharmacy 2006 Board Meetings • Pharmacy Guidelines for the Use of Controlled Substances for the Treatment of Pain • Pharmacy 2005 Approved CE Programs • Pharmacy 2003 Approved CE Programs • Pharmacy 2004 Approved CE Programs • Public Health Code • Pharmacy CE Requirements • Explanation of Continuing Education Requirements • Internship Hours • Administrative Rules • Pharmacy NAPLEX Examination • Michigan Board of Pharmacy Members Frequently Asked Questions • If I have been convicted of a felony or a misdemeanor, will this stop me from obtaining a Michigan license? • The application asks for the state(s) I have been licensed in and asks for the basis of licensure. What does that mean? What if I'm licensed in more than one state? Do you need verification from all states I have ever held a license in? • How long will you keep my licensure application on file? • How do I verify my Michigan license to another state? • Do I need to complete continuing education? • How can I change my name or address? • I need to verify whether someone has a license. How can I do that? • What happens if my license expires? • How long are the licenses issued for? Can I renew my license early? How will I know when I need to renew? • What is the purpose of the different types of applications? • How long does it take to process my application? • Is everything in my file complete? How can I find out what is missing? • How long does it take for your office to receive my correspondence? • I want to have Educational Testing Service (ETS) submit my TOEFL scores directly to the Board. What is the institutional code I need? • I work in more than one location. How can I have my license on display in all of my work areas? • I know that I have to do continuing education to renew my license. Since this is my first initial license and it's not for a full licensing period, do I need to complete CE's for my first renewal? • Can you give me information on my DEA license or how to get a DEA license? • Can I submit the renewal application for my controlled substance license before submitting the renewal for my professional license? • Can I pay for the renewal of both my professional license and the controlled substance license with the same check or money order? • Do I have to renew my controlled substance (CS)license if I am not currently living in Michigan and my professional license is active? Can I renew the CS license later, if I move back to Michigan? • My renewal date is coming up soon. I know that the license/registration will be valid until the expiration date after I renew. Since I will be moving next year, I only want to renew it for 1 year. Can I do that? • What if I don't earn enough continuing education credits? • How long do I need to keep my continuing education certificates? • Can I use any additional hours I earned over the required hours for the next renewal period? • Do I need to complete continuing education to renew my license? • Do I need to submit proof of my continuing education? Pharmacy Licensing Forms and Applications • Clinical Thermometer Certification Application • Physician Methadone Program Application • Sodium Pentobarbital Use Application • Controlled Substance Research License Application • Pharmacy Sign for Ephedrine/Pseudoephedrine Products Now Available • Suspended/Revoked License Reinstatement Application Packet • Disciplinary Limited License Reclassification Application Packet • Preceptor Application • Miscellaneous Pharmacy Change Application • Drug Control Application • Drug Control Add'l Location Application • Pharmacist Relicensure Application Packet • Manufacturer/Wholesaler Application Packet • Controlled Substance Additional Location License Application • Pharmacist Ed. Lmt.(Intern)Application Packet • Controlled Substance License Application • Pharmacy Application Packet • Pharmacist Application Packet • Pharmacy CE Program Sponsor Application • RENEWAL-License Renewal Application • Data Change/Duplicate License Request Form Accredited Professional Programs of Colleges and Schools of Pharmacy ACPE is the sole accreditation agency recognized by the U.S. Department of Education to accredit professional degree programs in pharmacy and, therefore, ACPE's directory is the only directory of accredited professional degree programs in pharmacy recognized by the U.S. Department of Education. The dates indicated below the programs represent the academic year of the most recent review and the academic year for the next currently scheduled review or consideration of accreditation, respectively. A review, as stated herein, usually refers to an on-site evaluation, but may refer to and be based upon a written report from the institution as requested by ACPE. University of Iowa College of Pharmacy 115 South Grand Avenue Iowa City, IA 52242 Jordan Cohen, PhD Dean Tel: 319-335-8794 FAX: 319-353-5594 E-Mail: jordan-cohen@uiowa.edu Web Site: http://pharmacy.uiowa.edu/ Doctor of Pharmacy (2003-2004; 2009-2010) KANSAS University of Kansas School of Pharmacy 1251 Wescoe Hall Drive Room 2056 Malott Hall Lawrence, KS 66045-7582 Kenneth Audus, PhD Dean Tel: 785-864-3591 FAX: 785-864-5265 E-Mail: audus@ku.edu Web Site: www.pharm.ukans.edu/dean/index.htm Doctor of Pharmacy (2001-2002; 2007-2008) KENTUCKY University of Kentucky College of Pharmacy 725 Rose Street, Suite 327 Lexington , KY 40536-0082 Kenneth Roberts, PhD Dean Tel: 859-323-7601 FAX: 859-257-2128 E-Mail: krobe2@pop.uky.edu Web Site: www.uky.edu/Pharmacy/ Doctor of Pharmacy (2003-2004; 2009-2010) LOUISIANA University of Louisiana at Monroe College of Pharmacy 700 University Avenue Monroe, LA 71209-0400 F. Lamar Pritchard, PhD Dean Tel: (318) 342-1600 FAX: (318) 342-1606 E-Mail: pritchard@ulm.edu Web Site: www.ulm.edu Doctor of Pharmacy (2001-2002; 2006-2007) Xavier University of Louisiana College of Pharmacy #1 Drexel Drive New Orleans, LA 70125 Wayne Harris, BS, MS, PhD Professor and Dean Tel: 504-520-7421 FAX: 504-520-7930 E-Mail: wharris@xula.edu Web Site: www.xula.edu/pharmacy Doctor of Pharmacy (2004-2005; 2006-2007) MARYLAND University of Maryland School of Pharmacy 20 North Pine Street Room 730 Baltimore, MD 21201-1180 David Knapp, PhD Dean Tel: 410-706-7651 FAX: 410-706-4012 E-Mail: dknapp@rx.umaryland.edu Web Site: www.pharmacy.umaryland.edu Doctor of Pharmacy (2005-2006; 2011-2012) MASSACHUSETTS Massachusetts College of Pharmacy and Health Sciences School of Pharmacy-Worcester 19 Foster Street Suite 400 Worcester, MA 01608 Michael Malloy, PharmD Dean Tel: 508-890-8855*1911 FAX: 508-890-8515 E-Mail: michael.malloy@wor.mcphs.edu Web Site: http://www.mcphs.edu/ Doctor of Pharmacy (2002-2003; 2006-2007) Massachusetts College of Pharmacy and Health Sciences School of Pharmacy-Boston 179 Longwood Avenue Boston, MA 02115 Douglas Pisano, PhD, RPh Dean Tel: 617-732-2781 FAX: 617-735-1082 E-Mail: douglas.pisano@bos.mcphs.edu Web Site: http:// www.mcphs.edu/ Doctor of Pharmacy (2003-2004; 2009-2010) Northeastern University Bouve College of Health Sciences School of Pharmacy 360 Huntington Avenue 206 Mugar Boston , MA 02115 John R. Reynolds, PharmD Interim Dean Tel: 617-373-3380 FAX: 617-373-7655 E-Mail: j.reynolds@neu.edu Web Site: www.bouve.neu.edu/pharmacy Doctor of Pharmacy (2002-2003; 2008-2009) MICHIGAN Formulary These are the brand name and generic drugs covered under the Commercial and Salud! Health Plans. PHP Formularies by Alphabetical listing PHP Formularies by Therapeutic class For Patients Find a Pharmacy - Please log into Pres Online and click on RxPortal in the Pharmacy Information Section. Maps and hours of Presbyterian pharmacies in Albuquerque Addresses and phone numbers of all pharmacies for Presbyterian patients Get your prescriptions delivered to your home with Walgreens Mail Service. Need a prescription refill? Order your refills via mail order 24 hours a day, seven days a week for delivery within 2 weeks. New prescription? These forms are in Adobe Acrobat (.pdf) format: Walgreens Mail Service: Pharmacy Tips Consejos Sobre el Servicio por Correo de Farmacia Registration and Prescription Order Form Formulario de Inscripcion y Orden Para Surtir Recetas Fax Order Form Formato para Ordenes por Fax Member Reimbursement Form For Pharmacists and other Healthcare Providers Payer Sheet for Pharmacies Adverse Drug Event Form (ADE) e-Pocrates - Access PHP formularies on your handheld device Micromedex Professional links Dosage guidelines for patients with compromised renal function. Presbyterian Health Plan Prior Authorization Criteria and Forms Request an addition to the Presbyterian Health Plan formulary Presbyterian Hospital Pharmacy Request an addition to the Presbyterian Hospital formulary Pharmacy Residency Program Pharmacy Practice Residency Program information Grievance and Appeals Presbyterian Health Plan welcomes feedback from our providers. File an "Appeal or Grievance" online. Please remember that a provider/practitioner has 1 year (12 months) from the date of service to file an appeal. Fraud and Abuse The Presbyterian Health Plan and Presbyterian Insurance Company's Special Investigative Unit (SIU) is responsible for the detection, investigation and reporting of potential fraud and abuse activity. We are required to cooperate with regulatory and law enforcement agencies in reporting any activity that appears to be suspicious in nature. According to the law, any information that we have concerning Careers in pharmacy A pharmacist is the member of the health team who knows most about all aspects of medicines. One of the most important advances in health care has been the development of highly specific and effective medicines - medicines that have virtually eliminated some diseases which were major killers in the recent past, and that have reduced the impact of many others. Pharmacists are the profession legally responsible for the supply of medicines. Their clinical role is concerned with medicines management, which seeks to improve health through the best use of medicines. Pharmacists work in community pharmacies, GPs surgeries, hospitals, industry, government and universities. How do you become a pharmacist? To be able to use the title of pharmacist in the UK, you must be registered with the Royal Pharmaceutical Society of Great Britain. Membership is granted to graduates with a degree in pharmacy from a UK university who have completed a year’s training at an approved establishment and passed a registration exam set by the Society. Training is usually arranged as either 12 months in a hospital or community pharmacy, but it can be done for 6 months in the pharmaceutical industry and 6 months in either hospital or community pharmacy. Pharmacy offers a variety of interesting careers. Pharmacists can work in a range of positions, with the possibility of flexible working across several of the sectors. Students taking a degree in pharmacy can feel confident that they are starting on a career in which there will always be a need for their services. Community pharmacy Three out of five pharmacists practise in community pharmacy. They will either own a pharmacy (‘chemist’s shop’) or be employed to manage and provide professional services within one. The duties of a community pharmacist involve supplying medicine for prescriptions, managing medicine for minor ailments of members of the public and giving advice on medicines. They also provide screening services and extra services to patients who are housebound. Many community pharmacists also provide a pharmaceutical service to nursing and care homes, involving medication reviews and advice on storage and administration of medicines. Some also work with general practitioners (GPs) on a sessional basis, for example, to develop more cost-effective prescribing and practice formularies. Hospital pharmacy Hospital pharmacists work on hospital wards or in outpatient clinics. Most hospital pharmacists specialise in a clinical area, such as paediatrics or intensive care, where they can work towards consultant status. Working as a hospital pharmacist, practitioners spend a lot of their time on wards with patients and other healthcare professionals as they work with doctors and nurses as part of a multidisciplinary patient-care team. Primary care Primary-care pharmacists work in GP practices. They do not provide a dispensing service, but work with GPs in developing practice formularies and more cost-effective and patient-centred prescribing. They are involved in a range of services, including drug use reviews, running clinics such as those for cholesterol monitoring, and reviewing the medication of patients on complex drug regimens. They normally have access to patients’ notes and medication profile. Pharmaceutical advisors Pharmaceutical advisors’ duties include analysing prescribing data at Primary care Trust (PCT) and GP-level, and development of prescribing policy and guidance to GPs on improving the cost-effectiveness of their prescribing. Many pharmaceutical advisors also advise PCTs on the development of community pharmacy services and on commissioning secondary care services where drug treatments are pivotal. Pharmaceutical industry As well as developing new drugs, the pharmaceutical industry is responsible for the production of existing drugs, ensuring that they are safe, effective and of the highest quality. Pharmacists are found in all areas of the industry. They use specialist knowledge and skills while keeping a broad view of drug treatment. The range of roles for pharmacists includes: Research Medical information Pharmacovigilance (monitoring product safety) Regulatory affairs (obtaining product licenses from health authorities) Medical writing Manufacturing and quality control Clinical trial supplies Sales National and international marketing General management Basic Organic Chemistry Foundation Biology * Foundation Mathematics * Academic Literacy * Foundation Physics * Social Pharmacy (1) Practical and Learning Skills Information Technology Laboratory Safety Core Tutorials Introduction to Hospital Pharmacy * Students take two of the four foundation courses, as advised by the Director of Undergraduate Studies Semester 2 Functional Group Chemistry Cellular Biology and Biochemistry Orientation to the Practice of Pharmacy Social Pharmacy (2) Physical Pharmacy Colloidal Dispersions Introductory Microbiology Core Tutorials Statistics Semester 3 Pharmaceutical Analysis Medicines Design 1 Social Pharmacy (3) Physiology 1 Microbiology Pathogenicity and Immunology Core Tutorials Semester 4 Social Pharmacy (4) Medicinal Chemistry Physiology 2 Forensic Science Core Tutorials Medicines Design 2 Drug Toxicity Semester 5 Pharmacology 1 Social Pharmacy (5) Management Extemporaneous Formulation Chemotherapy 1 Complementary Therapies/Phytopharmacy Pharmaceutical Microbiology Core Tutorials Disease Management (1A) Chemotherapy 2 Semester 6 Social Pharmacy (6) Pharmacology 2 Communication and the Appropriate Use of Medicines Law Relating to Pharmacy Drug Metabolism and Disposition Disease Management (1B) Rational Drug Design Physiological Biopharmaceutics Core Tutorials Semester 7 Disease Management (2) The Prescribing and Dispensing Process Law Relating to Pharmacy Social Pharmacy (7) Novel Drug Delivery Systems + Microbial Disease and Immunisation + Advanced Neuropharmacology + Pharmacokinetics - Dosage Regimen Design Semester 8 Molecular Toxicology + Cancer Biology and Therapy + Influences on Professional Practice + Production and Characterisation of Clinically and Commercially Important Drugs Disease Management (3) Pharmaceutical Care Essay ** Drug Development Workshop ** Prescribing ** At Hi-School Pharmacy, we care about you. That is why we we offer special services and promotions that you cannot get at any other drug store. We are locally owned and operated and care about our community. From online contests, special health screenings and more, we care about you. Here are some of the events we currently will be involved with. Click the picture for more details about the event. Maxor National Pharmacy Services Corporation is an employee-driven pharmacy and healthcare organization with a diverse offering of services, including our prescription benefit management service, MaxorPlus, to our array of integrated pharmacy services such as Maxor Pharmacy Consulting Services. Our employees, headquartered in Amarillo, Texas, provide award-winning service to our customers nationwide. Members returning to our Web site can refill prescriptions, find a nearby pharmacy and get answers to common questions. Maxor provides pharmacy services with you in mind, and we look forward to serving you. Maxor Pharmacy Management Services Maxor manages inpatient, outpatient and retail pharmacies by: Developing short and long-term strategic plans for financial performance improvement Providing on-site pharmacy operations management Providing Maxor pharmacy software solutions customized to your organization's needs Actively participating in Pharmacy and Therapeutics committees We improve utilization and cost management by: Implementing pharmacy management software solutions and data gathering tools Electronically monitoring, auditing and reconciling drug purchases Establishing cost and utilization benchmarks Identifying drug cost reduction opportunities Employing cost reduction strategies Online pharmacy is a unique concept where one can purchase medicines and pharmacy related products through web. Ideally an online pharmacy should present a wide selection of medicines, and all of them should be available to a customer in 24x7 quantum. Also one does not need to wait for doctors for purchasing the same. There is no need to produce any kind of prescription except one need to fill up a medical questionnaire. An online pharmacy has a panel of licensed physicians who shall review an order and issue a prescription. Then the licensed pharmacies dispense off with the medicines. A competent logistics company delivers the products at the location, which a customer desires. Online pharmacy is an interesting platform that has emerged with the popularity of e-commerce where one can purchase medicines and health products with the help of web. In truest sense online pharmacies should have wide array medicines, and all of them should be available to a customer at any point of time. Rather to be precise it should function in 24x7 quantum. So what are you waiting for? Start enjoying the convenience of ordering drugs and pharmacy related products from your office or home absolutely at your own convenience. There is a probability that people might raise their eyebrows when someone talks about a Mexican pharmacy. There are certain steps which one should follow while purchasing drugs from a Mexican pharmacy. Ideally one should first call his or her U.S. doctor to ask permission to purchase Mexican medicines. If the answer is an emphatic "NO!" then it is important to reconsider the effort. For example, some of the heart rhythm drugs are so sensitive that different brand names of the same chemical substance in the same dosage might react differently in the same person. On the other hand, if the ailment is not extremely sensitive such as drugs required for curing arthritis, antibiotics or asthma inhalants, one can join the 'Aware Consumer' bandwagon and go ahead for purchasing drugs from a Mexican pharmacy. There are certain other steps that one should follow while purchasing drugs from a Mexican pharmacy. If a patient decides to buy prescription drugs in Mexico then it is advisable that he or she should ask his U.S. based pharmacist to provide him or her with a small brochure called 'package insert' that which is normally attached to all bottles of U.S. wholesale medicines. This insert has exactly the same data and information that's listed in a huge reference book called Physician's Desk Reference (or PDR). The package insert contains an enormous amount of information about the medicine, its generic name, dosage formulations etc. When the same (i.e. PDR) is handed to a counter person in a Mexican pharmacy, they can cross reference the names and dosages, and provide a sample for the patient's approval. The counter person is experienced in identifying generic names and equivalences. That`s the highest level of expertise that one can expect out of them. It is advisable that a customer consults his or her U.S. based physician if he or she has the slightest doubt about the product. Also, it is important for the customer not to rely on the advice of the person behind the counter. Unlike their U.S. counterparts, they have no medical training! They are absolute salesman. As because Prescription drugs are regulated in the United States they are so powerful. They can be pose to be a peril if used improperly or paired with an incorrect, conflicting drug. Pharmacies are retail establishment where prescription medications as well as health related products are available. They are also known as a Chemist or Druggist. In order to run a pharmacy one has to procure drug license from the competent authority. Otherwise the operation of the pharmacy is termed as "illegal". The people who work in pharmacies are known as pharmacist. They should ideally be trained professionals who should know the pros and cons of medication and allied health business. Various Universities and institutions offer bachelors degree in pharmacy. A pharmacist ideally should be a holder of the said degree. Some or all of the following products are normally available at pharmacies. Like, Baby, child and skin care, Vitamins and supplements, personal care and bath materials. Products, which are related to sexual health like condoms, female contraceptives, sanitary napkins, Viagra, lubricants, sexual enhancers etc. are also normally available at pharmacies. With the influx of competition pharmacies are also selling various other health related products apart from medicines for example soaps, facial cleansers, deodorants, facial moisturizers, hair and foot care items, hosieries etc. Some pharmacies also has diabetes and cholesterol information centers too. Online Canadian pharmacy stores are increasingly becoming popular in the US. This is because a Canadian pharmacy sells online medications at cheaper prices. There are some drugs, which are sold both in Canada as well as in The United States of America. The same pharmaceutical company, with the same brand names and same packaging, may manufacture those drugs. In general, majority of the drugs that are sold in Canada are identical to the ones that are sold in The United States of America. When an American buyer orders medications from an online Canadian pharmacy he pays less than what an US based online store charges him. When a pharmaceutical company develops a new drug, they immediately go for patenting it giving an appropriate brand name. When the duration of that patent expires, other pharmaceutical companies may manufacture the same drug and sell it under their own banner name. These so called copied drugs are known as "generic" drugs. Like all other business when a number of companies produce the same product, competition develops and as a result the price goes down. This is the greatest advantage of a Canadian pharmacy. Yes, a Canadian pharmacy sells drugs at lower and more affordable price. Conversely, when a company holds a patent on a drug, there is a sort of monopoly that prevails for the company on the product. As a result the company can charge much higher prices for the drug. And as a customer we always land up paying more for the same. There is also an interesting feature aspect, which one should consider while comparing between the pharmacies of two countries. The value of the Canadian Dollar in relation to the U.S. Dollar plays a major role in the price difference between United States and Canada. For each U.S. dollar one exchanges in Canada, he or she receives approximately $1.50 in Canadian currency. Pharmacy is the profession that is associated with compounding and dispensing off with the required medication. Nowadays, the term includes other services which are related to patient care like clinical practice, medication review, and drug information. In fact some of these new roles are largely governed by a number of laws in various legislatures. The symbol that is most commonly associated with pharmacy is "mortar and pestle". Also Bowl of Hygeia, conical measures, green Greek cross,Gaper and caduceuses are some of the other symbols that pharmacy organisations often uses in their logos. The field of pharmacy can be divided into three main disciplines, namely: * Pharmaceutics * Pharmaceutical chemistry (In fact it is often referred as "medicianal chemistry") * Pharmacy practice There is no distinct boundaries between the aforesaid disciplines with other sciences, such as biochemistry.In fact it is frequently seen that people from various disciplines are researching together.Then there is Pharmacology which in fact is often considered as a fourth discipline of pharmacy. Pharmacology is required to the study of pharmacy in a generic way.Pharmacists are skilled healthcare professionals and often small-business owners, owning the pharmacy in which they practice, who works to ensure optimal health outcomes Best online pharmacies have certain characteristics. Online pharmacies have evolved strongly with the increasing popularity of e-commerce. Best online pharmacies should have a wide range of medicines, and all of them should be available to a customer in 24x7 quantum. A customer can order health and medication related products at a time, which suits his or her own convenience and that too from the comfort of his or her home. Best online pharmacies facilitate doorstep delivery of medicines. A competent logistics company is employed to deliver the same at a location, which a customer desires. Also Best online pharmacies do not compromise with security issue of a customer. Even the credit card payments (a wide range of credit cards are normally accepted by best online pharmacies) that they receive from the customers are processed by a safe and secure transaction server. Online pharmacies, if they want to be the very best in the market should adhere to the following parameters: * Prices-It should be on the lower side. * There should not be any kind of hidden costs. * Product quality---Nothing less than superior * It should be highly reliable. Reliabity in terms builds up trusts an d facilitates to get on going customers. * Speed of delivery---Absolutely should be within the turn around time. * Faster processing of orders. * There should methods and practices in place pertaining to customer service and subsequent follow up * Integrity and security of site. There should not be any cyber fraud. * Discrete billing and delivery * The establishment should be highly committed to Anti SPAM activity. Best Online pharmacies are normally classified into two categories namely "Brand Name Pharmacies" and "Generic Name Pharmacies". Some of the important brand name pharmacies are Viamedic, IntegraRX, USOnlineRx, NewPharm, Direct Pharmacy, Brand Pills, and European Pharmacy etc. Some of the important generic name pharmacies are Budget Medicines, Rx Mex, GenericPharmacy, RxPillsMD, Quality Generics, AllPills net, XLPharmacy etc. CanadaDrugs.comTM is Canada's largest International Prescription Service ("Internet") Pharmacy. Since opening in April of 2001, Canada DrugsTM has earned many pharmacy accreditations and become one of the most trusted Canadian discount pharmacies on the Internet. With over 250 full time staff, and over 3,000 prescriptions filled every day and shipped safely to patients internationally. You can trust us with your prescription drug purchase. Canada DrugsTM is located at: 24 Terracon Place, Winnipeg, MB, Canada, R2J 4G7. [full contact information] CanadaDrugs.comTM is licensed by the Manitoba Pharmaceutical Association: License # 32195. Canada DrugsTM is a Canadian pharmacy of choice for purchasing your discount prescription drugs and medication. At Canada DrugsTM, buying from an online Canadian pharmacy has never been easier. You can order prescription drugs and medication from Canada DrugsTM at discount prices by supplying a valid, prescription from a licensed physician. Our international online pharmacy also offers convenient prescription refills. At Canada DrugsTM, we maintain the highest standards in patient safety of any Canadian online pharmacy. We believe access to essential prescription drugs should be safe, convenient, and affordable for all. Canada DrugsTM is proud to be the first Canadian pharmacy to receive accreditation from IMPAC (Internet and Mailorder Pharmacy Accreditation Commission). Canada DrugsTM is also a certified member of the Canadian Internet Pharmacy Association (CIPA), the Better Business Bureau (BBB), VeriSign and is a 5 star rated pharmacy from Pharmacy Checker.com. As a premiere Canadian Internet-based and mail order pharmacy, Canada DrugsTM pharmacy is licensed by the Manitoba Pharmaceutical Association to distribute prescription medication. Pharmacy discount sales are increasingly becoming popular. For people with average income, paying hefty prices for medication poses tremendous financial pressure. With pharmacy discount programs common people now have the option to pay less for OTC and Prescription drugs. Studies indicate that a common American is now ready to go to a Canadian or Mexican online pharmacy if they have a pharmacy discount offer running! If you are tired of paying huge medication bills, it is time to opt for pharmacy discount offers. A search on the net would help you to locate the discount pharmacies. Online pharmacy discount offers help you save money if you buy your medications online. To avail yourself of an attractive pharmacy discount sale you need to search for the online discount pharmacies. An online pharmacy discount offer can save up to 75% of your medications bills. And not only that, there are reputable pharmacies online that offer free shipping, doorstep delivery, attractive refill packages and many other sweet deals you would love to grab as a consumer. Many big online pharmacy stores offer pharmacy discount cards or special refill discounts for regular customers. They want to 'reward' their regular clients with special discounts. You can save money if you purchase medications from such stores. Online pharmacies are becoming increasingly popular worldwide. Availability of free shipping, discount prices, and 24/7 customer services are some of the main factors that propel the buyers to an online pharmacy. Discount is the most important factor that tempting the US medications buyers go online as medicines are very expensive when bought from traditional shops. There are certain legal parameters, which a Pharmacy Online follows, and tries to abide by while doing business transaction with a client. The intention to write this article is to provide the readers an insight of the same. When a customer places an order through Pharmacy Online, he or she legally affirms that: * They do not have any kind of allergies, sensitivities or intolerance to any of the products that are ordered * They do not have any known medical conditions predisposing to adverse reactions to any products ordered * They are not taking any parallel medication course with which the products ordered are likely to clash. * For ordering prescription items a customer has to confirm that they have received the required guidance from a physician about the indications, actions and side effects of any medications they have been prescribed. This should also, include the likely results of not taking the medication * For non-prescription items: the customer has to shoulder all responsibility for any adverse outcomes which might occur as a result of using the product(s) that they have ordered The Pharmacy Online also does not accept any responsibility for any kind of medical eventualities after a client uses online consulting service. Pharmacies are retail establishment where prescription medications as well as health related products are available. They are also known as a Chemist or Druggist. In order to run a pharmacy one has to procure drug license from the competent authority. Otherwise the operation of the pharmacy is termed as "illegal". The people who work in pharmacies are known as pharmacist. They should ideally be trained professionals who should know the pros and cons of medication and allied health business. Various Universities and institutions offer bachelors degree in pharmacy. A pharmacist ideally should be a holder of the said degree. Some or all of the following products are normally available at pharmacies. Like, Baby, child and skin care, Vitamins and supplements, personal care and bath materials. Products, which are related to sexual health like condoms, female contraceptives, sanitary napkins, Viagra, lubricants, sexual enhancers etc. are also normally available at pharmacies. With the influx of competition pharmacies are also selling various other health related products apart from medicines for example soaps, facial cleansers, deodorants, facial moisturizers, hair and foot care items, hosieries etc. Some pharmacies also has diabetes and cholesterol information centers too. Pharmacy discount sales are increasingly becoming popular. For people with average income, paying hefty prices for medication poses tremendous financial pressure. With pharmacy discount programs common people now have the option to pay less for OTC and Prescription drugs. Studies indicate that a common American is now ready to go to a Canadian or Mexican online pharmacy if they have a pharmacy discount offer running! If you are tired of paying huge medication bills, it is time to opt for pharmacy discount offers. A search on the net would help you to locate the discount pharmacies. Online pharmacy discount offers help you save money if you buy your medications online. To avail yourself of an attractive pharmacy discount sale you need to search for the online discount pharmacies. An online pharmacy discount offer can save up to 75% of your medications bills. And not only that, there are reputable pharmacies online that offer free shipping, doorstep delivery, attractive refill packages and many other sweet deals you would love to grab as a consumer. Many big online pharmacy stores offer pharmacy discount cards or special refill discounts for regular customers. They want to 'reward' their regular clients with special discounts. You can save money if you purchase medications from such stores. Online pharmacies are becoming increasingly popular worldwide. Availability of free shipping, discount prices, and 24/7 customer services are some of the main factors that propel the buyers to an online pharmacy. Discount is the most important factor that tempting the US medications buyers go online as

Phendimetrazine (Bontril®) is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances. In the United States, phendimetrazine is a Schedule III controlled substance under the Uniform Controlled Substances Act of 1970. Phendimetrazine is used clinically in the form of phendimetrazine tartrate. Approximately 30% of a given dose of phendimetrazine is metabolized into phenmetrazine, which may account for part of its anorectic effect, and probably also influences abuse potential; individuals who metabolise a greater proportion of phendimetrazine into phenmetrazine are more likely to develop problems with dependence and addiction. Phendimetrazine tartrate, as the dextro isomer, has the chemical name of (2S.3S)-3, 4-Dimethyl-2-phenylmorpholine L-(*)-tartrate (1.1). Its molecular weight is 341.36. Phendimetrazine tartrate is a white, odorless crystalline powder. It is freely soluble in water; sparingly soluble in warm alcohol, insoluble in chloroform, acetone, ether and benzene. Each tablet, for oral administration, contains 35mg of phendimetrazine tartrate. In addition, each tablet contains the following inactive ingredients: Lactose USP, Magnesium Stearate NF, Colloidal Silicon Dioxide, Microcrystalline Cellulose NF, Starch NF (Modified Corn Starch). Additional inactive ingredients are present as follows: Phendimetrazine 35mg Gray Tablet Contains: Activated Charcoal USP. Sterotex Food Grade. Phendimetrazine 35mg Pink Tablet contains: FD&C Red #3. Phendimetrazine 35mg Speckled Tablet contains: Calcium Stearate NF, FD&C Blue #1, FD&C Yellow #5, and sucrose. What are phendimetrazine capsules or tablets? (Back to top) PHENDIMETRAZINE (Bontril PDM®, Phendiet®, Phenzene®, Plegine®) helps you lose weight. Combined with a reduced calorie diet, it can help you reduce weight by decreasing your appetite. Generic phendimetrazine is available. What should my health care professional know before I take phendimetrazine? (Back to top) They need to know if you have any of these conditions: •diabetes •glaucoma •heart disease •high blood pressure •thyroid disease •taken other medicines to lose weight in the past year •an unusual or allergic reaction to phendimetrazine, other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should I take this medicine? (Back to top) Take phendimetrazine capsules or tablets by mouth. Follow the specific directions on the prescription label. Swallow the capsules or tablets with a drink of water at least 1 hour before eating. Do not take your medicine more often than directed. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. What if I miss a dose? (Back to top) If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. What drug(s) may interact with phendimetrazine? (Back to top) •linezolid •medicines for blood pressure •medicines for diabetes •medicines for mental depression •other medicines or herbal products for weight loss or to decrease appetite Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects may I notice from taking phendimetrazine? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: •breathlessness on exertion •chest pain •depression or severe changes in mood •dry cough •heart palpitations •increased blood pressure •severe dizziness •problems urinating •vomiting Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): •a false sense of well being •blurred vision or other eye problems •changes in sexual ability or desire •constipation •diarrhea •difficulty sleeping •dizziness •dry mouth •fatigue •flushing •headache •irritability •nervousness or restlessness •nausea •sweating •unpleasant taste What should I watch for while taking phendimetrazine? (Back to top) Notify your physician immediately if you become short of breath while doing your normal activities. Keep in mind that phendimetrazine was intended to be used in addition to a healthy diet and exercise. The best results are achieved this way. While your prescriber or health care professional will most likely prescribe phendimetrazine for only a few months; however, some people have used it for longer periods. Eventually your weight loss may "level out". At that point, the drug will only help you maintain your new weight. Do not increase or in any way change your dose without consulting your prescriber. Do not drive, use machinery, or do anything that requires mental alertness or physical coordination until you know how phendimetrazine affects you. Alcohol can increase the possibility of experiencing side effects with phendimetrazine. Therefore, it is best to avoid alcoholic drinks. Where can I keep my medicine? (Back to top) Keep out of the reach of children in a container that small children cannot open. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date. Use caution when driving, operating machinery, or performing other hazardous activities. Phendimetrazine may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities. • Phendimetrazine is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually. • Do not crush, chew, or open any "once-daily" phendimetrazine tablets or capsules. Swallow them whole. Phendimetrazine is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an "anorectic" or "anorexigenic" drug. Phendimetrazine stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite. • Phendimetrazine is used as a short-term supplement to diet and exercise in the treatment of obesity. • Phendimetrazine may also be used for purposes other than those listed in this medication guide. Cardiovascular - Palpitation, chest pain, tachycardia, arrhythmias and hypertension are common; cardiovascular collapse can occur in severe poisoning. Myocardial ischaemia, infarction and ventricular dysfunction are described. Central Nervous System (CNS) - Stimulation of CNS, tremor, restlessness, agitation, insomnia, increased motor activity, headache, convulsions, coma and hyperreflexia are described. Stroke and cerebral vasculitis have been observed. Gastrointestinal - Vomiting, diarrhoea and cramps may occur. Acute transient ischaemic colitis has occurred with chronic methamphetamine abuse. Genitourinary - Increased bladder sphincter tone may cause dysuria, hesitancy and acute urinary retention. Renal failure can occur secondary to dehydration or rhabdomyolysis. Renal ischaemia may be noted. Dermatologic - Skin is usually pale and diaphoretic, but mucous membranes appear dry. Endocrine - Transient hyperthyroxinaemia may be noted. Metabolism - Increased metabolic and muscular activity may result in hyperventilation and hyperthermia. Weight loss is common with chronic use. Fluid/Electrolyte - Hypo- and hyperkalaemia have been reported. Dehydration is common. Musculoskeletal - Fasciculations and rigidity may be noted. Rhabdomyolysis is an important consequence of severe amphetamine poisoning. Psychiatric - Agitation, confusion, mood elevation, increased wakefulness, talkativeness, irritability and panic attacks are typical. Chronic abuse can cause delusions and paranoia. A withdrawal syndrome occurs after abrupt cessation following chronic use. 2.3 Diagnosis The diagnosis of acute amphetamine poisoning is made on the history of exposure or abuse, and the characteristic features of CNS and cardiovascular stimulation. The presence of amphetamines in urine or blood can support the diagnosis but is not helpful in management. Whilst some patients show signs of toxicity at blood concentrations of 20 µg/L, chronic abusers of amphetamine have been known to have blood concentration of up to 3000 µg/L. 2.4 First aid measures and management principles Management of amphetamine and its complications is essentially supportive. The initial priority is stabilisation of the airway, breathing and circulation. Monitoring of pulse, blood pressure, oxygenation, core temperature and cardiac rhythm should instituted. Supplemental oxygen should be administered. Specific supportive care measures that may be necessary include: maintenance of hydration, control of seizures, relief of agitation, control of hyperthermia, control of hypertension, management of rhabdomyolysis. Decontamination with oral activated charcoal is appropriate if the patient is conscious. There are no suitable methods of enhancing elimination of amphetamine and no specific antidotes. 3. PHYSICO-CHEMICAL PROPERTIES 3.1 Origin of the substance Synthetic 3.2 Chemical structure Phendimetrazine tartrate Chemical name: 3,4-Dimethyl-2-phenyl-morpholine tartrate Other chemical names: D-3,4-Dimethyl-2-phenyl-morpholine tartrate Morpholine, 3,4-dimethyl-2-phenyl-, (+)-, tartrate (1:1) Molecular formula: C12H17NO,C4H6O6 Molecular weight: 341.4 3.3 Physical properties Use caution when driving, operating machinery, or performing other hazardous activities. Phendimetrazine may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities. habit Phendimetrazine is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually. nocrush Do not crush, chew, or open any "once-daily" phendimetrazine tablets or capsules. Swallow them whole. What is phendimetrazine? Phendimetrazine is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an "anorectic" or "anorexigenic" drug. Phendimetrazine stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite. Phendimetrazine is used as a short-term supplement to diet and exercise in the treatment of obesity. Phendimetrazine may also be used for purposes other than those listed in this medication guide. Who should not take phendimetrazine? donot You cannot take phendimetrazine if you * have heart disease or high blood pressure; * have arteriosclerosis (hardening of the arteries); * have glaucoma; * have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days; or * have a history of drug or alcohol abuse. Before taking this medication, tell your doctor if you have * problems with your thyroid, * an anxiety disorder, * epilepsy or another seizure disorder, or * diabetes. You may not be able to take phendimetrazine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. nopreg It is not known whether phendimetrazine will harm an unborn baby. Do not take phendimetrazine without first talking to your doctor if you are pregnant. nobrfeed It is also not known whether phendimetrazine passes into breast milk. Do not take phendimetrazine without first talking to your doctor if you are breast-feeding a baby. How should I take phendimetrazine? Take phendimetrazine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. water Take each dose with a full glass of water. stomach Phendimetrazine is usually taken once a day (sustained release formula) or two to three times daily (immediate-release formula) before meals on an empty stomach. Do not take phendimetrazine in the evening because it may cause insomnia. nocrush Do not crush, chew, or open any "once-daily" phendimetrazine tablets or capsules. Swallow them whole. donot Never take more of this medication than is prescribed for you. Too much phendimetrazine could be very dangerous to your health. rt Store phendimetrazine at room temperature away from moisture and heat. What happens if I miss a dose? donot Take the missed dose as soon as you remember. However, if it is almost time for your next dose or if it is already evening, skip the missed dose and take only your next regularly scheduled dose. A dose taken too late in the day will cause insomnia. Do not take a double dose of this medication. What happens if I overdose? emt Seek emergency medical attention. Symptoms of a phendimetrazine overdose include restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures. What should I avoid while taking phendimetrazine? dizzy Use caution when driving, operating machinery, or performing other hazardous activities. Phendimetrazine may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities. Do not take phendimetrazine late in the day. A dose taken too late in the day can cause insomnia. What are the possible side effects of phendimetrazine? emt If you experience any of the following serious side effects, stop taking phendimetrazine and seek emergency medical attention: * an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); * an irregular heartbeat or very high blood pressure (severe headache, blurred vision); or * hallucinations, abnormal behavior, or confusion. Other, less serious side effects may be more likely to occur. Continue to take phendimetrazine and talk to your doctor if you experience * restlessness or tremor, * nervousness or anxiety, * headache or dizziness, * insomnia, * dry mouth or an unpleasant taste in your mouth, * diarrhea or constipation, or * impotence or changes in your sex drive. habit Phendimetrazine is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect phendimetrazine? You cannot take phendimetrazine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days. Changes in insulin and other diabetes drug therapies may be necessary during treatment with phendimetrazine. Phendimetrazine may reduce the effects of guanethidine (Ismelin). This could lead to an increase in blood pressure. Tell your doctor if you are taking guanethidine. Before taking this medication, tell your doctor if you are taking a tricyclic antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), doxepin (Sinequan), nortriptyline (Pamelor), imipramine (Tofranil), clomipramine (Anafranil), protriptyline (Vivactil), or desipramine (Norpramin). These drugs may decrease the effects of phendimetrazine. Drugs other than those listed here may also interact with phendimetrazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. Where can I get more information? Your pharmacist has more information about phendimetrazine written for health professionals that you may read. What does my medication look like? Phendimetrazine is available with a prescription under several brand names. The immediate-release formulation is available in 35 mg tablets and capsules. The sustained-release formulation is available in 105 mg capsules. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

SOMA's interdisciplinary team approach brings a unique perspective to each project combining real world, academic and regulatory experience. For more in-depth information regarding our staff members contact SOMA. Areas of Expertise of SOMA Staff &Associates • Occupational Medicine • Industrial Hygiene/Exposure Modeling • Occupational Health Nursing • Information Science • Neurology/Neuropsychology/Psychiatry • Pulmonology Animal Toxicology • Risk Assessment • Dermatology • Allergy/lmmunology • Epidemiology/Biostatistics • Pathology • Oncology • Radiology • Gastroenterology • Cardiology • Endocrinology • Orthopedics Buy Soma online Learn more about usage, cautions, and possible side effects. Prescription Soma Tablets Chemical Name: CARISOPRODOL (kar-eye-soe-PROE-dole) Common uses of prescription Soma containing Carisoprodol Carisoprodol is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Soma drugs / carisoprodol may also be used for purposes other than those listed in this medication guide. return to top Before using Prescription Soma Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. USE OF SOMA DRUGS is not recommended if you are also taking cyclobenzaprine or medicine for depression or other emotional or mood disorders. If you are taking any of these medicines, be sure your doctor knows. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking bupropion, narcotic analgesics, carbamazepine, or have a history of seizures. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine. Use caution when driving, operating machinery, or performing other hazardous activities. soma / carisoprodol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking soma / carisoprodol. Also, in combination with aspirin, alcohol can be very damaging to your stomach. Watch for bloody, black, or tarry stools or blood in your vomit. This could mean damage to your stomach. Never take more of this medication than is prescribed for you. If your pain is not being adequately treated, talk to your doctor. return to top Directions Follow the directions for using this medicine provided by your doctor. STORE THIS MEDICINE at room temperature, away from heat and light. IF YOU MISS A DOSE OF THIS MEDICINE, take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of soma / carisoprodol. Keep your doses at least 4 hours apart from one another.take it as soon as possible. Do NOT take 2 doses at once. return to top Cautions DO NOT EXCEED THE RECOMMENDED DOSE OR TAKE THIS MEDICINE for longer than prescribed. IF YOU EXPERIENCE difficulty breathing or tightness of chest; swelling of eyelids, face, or lips; or develop a rash or hives, tell your doctor immediately. Do not take any more of this medicine unless your doctor tells you to do so. AVOID ALCOHOL while you are using this medicine. This medicine will add to the effects of alcohol and other depressants. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. Caution should be used in the elderly since they may be more sensitive to the effects of this drug. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine. Do not take soma / carisoprodol if you have acute intermittent porphyria. Codeine is habit forming and should only be used under close supervision if you have an alcohol or drug addiction. Before taking this medication, tell your doctor if you have: kidney disease liver disease an ulcer in your stomach or intestines a bleeding or blood-clotting disorder urinary retention an enlarged prostate hypothyroidism a head injury addison's disease You may not be able to take soma / carisoprodol, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. It is not known whether soma / carisoprodol will harm an unborn baby. Do not take soma / carisoprodol without first talking to your doctor if you are pregnant. It is also not known whether soma / carisoprodol passes into breast milk. Do not take soma / carisoprodol without first talking to your doctor if you are breast-feeding a baby. Soma / carisoprodol is not approved for use in children younger than 12 years of age. return to top Possible side effects If you experience any of the following serious side effects, stop taking soma / carisoprodol and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); paralysis (loss of feeling) or extreme weakness vision loss agitation or tremor red, black, or bloody stools blood in your vomit other, less serious side effects may be more likely to occur Continue to take soma / carisoprodol and talk to your doctor if you experience: drowsiness or dizziness headache depression blurred vision or small pupils insomnia; hiccups faint ringing in the ears nausea, vomiting, or constipation Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. return to top Drug interactions Many drugs can increase the effects of soma / carisoprodol and lead to heavy sedation. Before taking this medication, tell your doctor if you are taking any of the following medicines: antihistamines such as brompheniramine (Dimetane, Bromfed, others) chlorpheniramine (Chlor-Trimeton Teldrin, others) azatadine (Optimine) clemastine (Tavist) narcotics (pain killers) such as meperidine (Demerol) morphine (MS Contin, MSIR, others) propoxyphene (Darvon, Darvocet) hydrocodone (Lorcet, Vicodin) oxycodone (Percocet, Percodan) fentanyl (Duragesic) codeine (Fiorinal, Fioricet, Tylenol #3, others) sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal) secobarbital (Seconal) phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin) mesoridazine (Serentil) perphenazine (Trilafon) prochlorperazine (Compazine) thioridazine (Mellaril), and trifluoperazine (Stelazine) antidepressants such as doxepin (Sinequan) imipramine (Tofranil) nortriptyline (Pamelor) fluoxetine (Prozac) paroxetine (Paxil) sertraline (Zoloft) phenelzine (Nardil) tranylcypromine (Parnate) Other over-the-counter and prescription drugs may increase the effects of aspirin and cause dangerous side effects: oral anticoagulants such as warfarin (Coumadin) nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Rufen, others) ketoprofen (Orudis, Oruvail) naproxen (Anaprox, Naprosyn, Aleve) other commonly used NSAIDs, including diclofenac (Voltaren, Cataflam), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), and tolmetin (Tolectin) other salicylates (forms of aspirin) such as salsalate (Disalcid), choline salicylate, and magnesium salicylate bismuth subsalicylate in drugs such as Pepto-Bismol; and calcium supplements and antacids. other drugs that should not be combined with aspirin and carisoprodol include steroids such as prednisone (Deltasone) oral antidiabetic drugs such as glipizide (Glucotrol) and glyburide (Micronase, Diabeta) alcohol lithium (Lithobid, Eskalith, others) cyclosporine (Sandimmune) Drugs other than those listed here may also interact with soma / carisoprodol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. return to top If you take too much If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include cold and clammy skin, low body temperature, slowed breathing, slowed heartbeat, drowsiness, dizziness, lightheadedness, seizures, deep sleep, and loss of consciousness. Seek emergency medical attention. Symptoms of an aspirin soma / carisoprodol overdose include: headache ringing in the ears dim vision small pupils nausea vomiting diarrhea sweating increased thirst low blood pressure (weakness, fainting, confusion) decreased breathing unconsciousness. return to top Additional information DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out. Soma This page contains drug information on Soma. The information provided includes the following: what is Soma the possible side effects of Soma what happens if you miss a dose of Soma what happens if you overdose with Soma the most important information about Soma how to use Soma other drugs that may affect Soma what to avoid while using Soma Generic Name: carisoprodol (kar eye soe PROE dole) Brand Names: Soma, Vanadom What is the most important information I should know about carisoprodol? • Use caution when driving, operating machinery, or performing other hazardous activities. Carisoprodol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking carisoprodol. What is carisoprodol? • Carisoprodol is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. • Carisoprodol is used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. • Carisoprodol may also be used for purposes other than those listed in this medication guide. Who should not take carisoprodol? • Do not take carisoprodol if you have acute intermittent porphyria. • Before taking carisoprodol, tell your doctor if you have kidney or liver disease. You may need a lower dose or special monitoring during your therapy. • It is not known whether carisoprodol will harm an unborn baby. Do not take carisoprodol without first talking to your doctor if you are pregnant. • It is also not known whether carisoprodol passes into breast milk. Do not take carisoprodol without first talking to your doctor if you are breast-feeding a baby. • Carisoprodol is not approved for use in children younger than 12 years of age. How should I take carisoprodol? • Take carisoprodol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. • Take each dose with a full glass of water. • The maximum amount of carisoprodol you should take in one day is 1,400 mg (4 tablets). • Store carisoprodol at room temperature away from moisture and heat. What happens if I miss a dose? • Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication. Try to keep your doses at least 4 hours apart. What happens if I overdose? • Seek emergency medical attention. • Symptoms of a carisoprodol overdose include low blood pressure (weakness, fainting, confusion), decreased breathing, and unconsciousness. What should I avoid while taking carisoprodol? • Use caution when driving, operating machinery, or performing other hazardous activities. Carisoprodol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking carisoprodol. What are the possible side effects of carisoprodol? • If you experience any of the following serious side effects, stop taking carisoprodol and seek emergency medical attention: · an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); · paralysis (loss of feeling) or extreme weakness; · vision loss; or · agitation or tremor. • Other, less serious side effects may be more likely to occur. Continue to take carisoprodol and talk to your doctor if you experience · drowsiness or dizziness; · headache; · depression; · blurred vision; · insomnia; or · hiccups. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect carisoprodol? • Many drugs can increase the effects of carisoprodol, which can lead to heavy sedation. Before taking this medication, tell your doctor if you are taking any of the following medicines: · antihistamines such as brompheniramine (Dimetane, Bromfed, others), chlorpheniramine (Chlor-Trimeton, Teldrin, others), azatadine (Optimine), clemastine (Tavist), and many others; · narcotics (pain killers) such as meperidine (Demerol), morphine (MS Contin, MSIR, others), propoxyphene (Darvon, Darvocet), hydrocodone (Lorcet, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), and codeine (Fiorinal, Fioricet, Tylenol #3, others); · sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal), and secobarbital (Seconal); · phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), and trifluoperazine (Stelazine); or · antidepressants such as doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), phenelzine (Nardil), and tranylcypromine (Parnate). • Drugs other than those listed here may also interact with carisoprodol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. Where can I get more information? • Your pharmacist has more information about carisoprodol written for health professionals that you may read. Soma is a medication that acts as a muscle relaxant, usually for the purpose of helping patients deal with the pain associated with injury. On our site, generic Soma (known as Carisoprodol) is made available to consumers for the lowest prices online. The reason so many people decide to purchase their Soma online from our website is the service that we offer, and our low prices. That, combined with the convenience of online ordering, and not needing a prior prescription make ordering your Soma online from us an easy decision for you to make. If you are in the process of recovering from an injury, and need Carisoprodol to help during the recovery period, you can buy it online here and have it in your hands in as little as one or two business days. Keep in mind that Soma is not intended to directly heal the injury you have suffered. Rather, it works to temporarily suppress the pain so that you can more comfortably go on with your normal daily activities. Although, it is usually regarded as best to rest an injury such as that as much as possible. A good amount of rest, supervised physical therapy, and your daily dosages of Soma will often form a good plan for getting through and past a muscular injury. Soma is taken orally. A single pill is ingested, three times a day. It is recommended that you take it with food, or with milk, to minimize the likelihood that you will suffer an upset stomach as a result of taking the medication. When taking Carisoprodol, you should be very careful if you intend to ingest alcohol or alcoholic beverages. This medication may very well intensify the effects of the alcohol you ingest. In addition, you should refrain from operating dangerous machinery or from operating an automobile until you have an understanding of how having this medication in your system will effect your ability to perform the mental or physical tasks necessary for those activities. As always, keep this and all other medications (prescription, as well as over the counter) stored safely out of the reach of children. Soma, or its generic form called Carisoprodol is a muscle relaxant which works by blocking nerve impulses that are sent to your brain. Many poeple use Soma to treat injuries and other painful muscular conditions. It has the best results when taken in combination with rest, physical therapy and other measures. Although people find it benificial to use for other purposes, it is mainly meant to treat pain and stiffness of muscle injuries including the following: strains sprains and muscle spasms Take Soma exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.Take each dose with a full glass of water.The maximum amount of Soma you should take in one day is 1,400 mg (4 tablets).Store Soma at room temperature away from moisture and heat.Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication. Try to keep your doses at least 4 hours apart. Carisoprodol belongs to the category of drugs known as muscle relaxants. These drugs directly react on the Central Nervous System to reduce pain. Soma is known to produce very few side effects which is why doctors prefer prescribing soma instead of other muscle-relaxants. The side effects from Soma are known to emerge as soon as you start taking the medication. In the starting days you may encounter problems like headache, body ache and other troubles. But once your body adapts to the medication, these side effects usually go away. You should continue using Soma even after you see few side effects during the early stages. However if any of the problem remains for longer than expected period you should contact your doctor immediately. It may happen sometime that drug may affect some patients adversely. The following is a list of side effects that may occur in the beginning stages of using Soma: SOMA' (carisoprodol) Tablets, USP is available as 350 mg round, white tablets. Chemically, carisoprodol is N-isopropyl-2- methyl-2-propyl-1,3-propanediol dicarbamate. Carisoprodol is a white, crystalline powder, having a mild, characteristic odor and a bitter taste. It is very slightly soluble in water; freely soluble in alcohol, in chloroform, and in acetone; its solubility is practically independent of pH. Carisoprodol is present as a racemic mixture. The molecular formula is C 12 H 24 N 2 O 4 , with a molecular weight of 260.33. The structural formula is: Carisoprodol produces muscle relaxation in animals by blocking interneuronal activity in the descending reticular formation and spinal cord. The onset of action is rapid and effects last four to six hours. INDICATIONS Carisoprodol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Carisoprodol does not directly relax tense skeletal muscles in man. CONTRAINDICATIONS Acute intermittent porphyria as well as allergic or idiosyncratic reactions to carisoprodol or related compounds. WARNINGS Idiosyncratic Reactions --On very rare occasions, the first dose of carisoprodol has been followed by idiosyncratic symptoms appearing within minutes or hours. Symptoms reported include: extreme weakness, transient quadriplegia, dizziness, ataxia, temporary loss of vision, diplopia, mydriasis, dysarthria, agitation, euphoria, confusion, and disorientation. Symptoms usually subside over the course of the next several hours. Supportive and symptomatic therapy, including hospitalization, may be necessary. Usage in Pregnancy and Lactation --Safe usage of this drug in pregnancy or lactation has not been established. Therefore, use of this drug in pregnancy, in nursing mothers, or in women of childbearing potential requires that the potential benefits of the drug be weighed against the potential hazards to mother and child. Carisoprodol is present in breast milk of lactating mothers at concentrations two to four times that of maternal plasma. This factor should be taken into account when use of the drug is contemplated in breast-feeding patients. Usage in Children --Because of limited clinical experience, `SOMA' is not recommended for use in patients under 12 years of age. Potentially Hazardous Tasks --Patients should be warned that this drug may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a motor vehicle or operating machinery. Additive Effects --Since the effects of carisoprodol and alcohol or carisoprodol and other CNS depressants or psychotropic drugs may be additive, appropriate caution should be exercised with patients who take more than one of these agents simultaneously. Drug Dependence --In dogs, no withdrawal symptoms occurred after abrupt cessation of carisoprodol from dosages as high as 1 gm/kg/day. In a study in man, abrupt cessation of 100 mg/kg/day (about five times the recommended daily adult dosage) was followed in some subjects by mild withdrawal symptoms such as abdominal cramps, insomnia, chilliness, headache, and nausea. Delirium and convulsions did not occur. In clinical use, psychological dependence and abuse have been rare, and there have been no reports of significant abstinence signs. Nevertheless, the drug should be used with caution in addiction-prone individuals. PRECAUTIONS Carisoprodol is metabolized in the liver and excreted by the kidney; to avoid its excess accumulation, caution should be exercised in administration to patients with compromised liver or kidney function. ADVERSE REACTIONS Central Nervous System --Drowsiness and other CNS effects may require dosage reduction. Also observed: dizziness, vertigo, ataxia, tremor, agitation, irritability, headache, depressive reactions, syncope, and insomnia. (See also Idiosyncratic Reactions under "Warnings." ) Allergic or Idiosyncratic --Allergic or idiosyncratic reactions occasionally develop. They are usually seen within the period of the first to fourth dose in patients having had no previous contact with the drug. Skin rash, erythema multiforme, pruritus, eosinophilia, and fixed drug eruption with cross reaction to meprobamate have been reported with carisoprodol. Severe reactions have been manifested by asthmatic episodes, fever, weakness, dizziness, angioneurotic edema, smarting eyes, hypotension, and anaphylactoid shock. (See also Idiosyncratic Reactions under "Warnings." ) In case of allergic or idiosyncratic reactions to carisoprodol, discontinue the drug and initiate appropriate symptomatic therapy, which may include epinephrine, antihistamines, and in severe cases corticosteroids. In evaluating possible allergic reactions, also consider allergy to excipients (information on excipients is available to physicians on request). Cardiovascular --Tachycardia, postural hypotension, and facial flushing. Gastrointestinal --Nausea, vomiting, hiccup, and epigastric distress. Hematologic --Leukopenia, in which other drugs or viral infection may have been responsible, and pancytopenia, attributed to phenylbutazone, have been reported. No serious blood dyscrasias have been attributed to carisoprodol. DOSAGE AND ADMINISTRATION The usual adult dosage of `SOMA' (carisoprodol) Tablets, USP is one 350 mg tablet, three times daily and at bedtime. Usage in patients under age 12 is not recommended. OVERDOSAGE Overdosage of carisoprodol has produced stupor, coma, shock, respiratory depression, and, very rarely, death. The effects of an overdosage of carisoprodol and alcohol or other CNS depressants or psychotropic agents can be additive even when one of the drugs has been taken in the usual recommended dosage. Any drug remaining in the stomach should be removed and symptomatic therapy given. Should respiration or blood pressure become compromised, respiratory assistance, central nervous system stimulants, and pressor agents should be administered cautiously as indicated. Carisoprodol is metabolized in the liver and excreted by the kidney. Although carisoprodol overdosage experience is limited, the following types of treatment have been used successfully with the related drug meprobamate: diuresis, osmotic (mannitol) diuresis, peritoneal dialysis, and hemodialysis (carisoprodol is dialyzable). Careful monitoring of urinary output is necessary and caution should be taken to avoid overhydration. Observe for possible relapse due to incomplete gastric emptying and delayed absorption. Carisoprodol can be measured in biological fluids by gas chromatography (Douglas, J. F. et al.: J Pharm Sci 58: 145, 1969). Carisoprodol, or Generic Soma, (generic for Soma) is a muscle relaxant recommended for muscle injury, musculoskeletal condition, and muscle related spasm. It is combined therapy of rest, exercise and medication. The drug directly affects the Central Nervous System (CNS). It blocks the pain receptors from reaching the brain thus relieving the pain. Carisoprodol is relatively potent and also brings down the possibility of side effects. Soma' Compound with Codeine is a combination product containing carisoprodol, a centrally-acting muscle relaxant, plus aspirin, an analgesic with antipyretic and anti-inflammatory properties and codeine phosphate, a centrally-acting narcotic analgesic. It is available as a two-layered, white and yellow, oval-shaped tablet for oral administration. Each tablet contains carisoprodol 200 mg, aspirin 325 mg, and codeine phosphate 16 mg. Chemically, carisoprodol is N-isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate. Its empirical formula is C 12 H 24 N 2 O 4 , with a molecular weight of 260.33. The structural formula is: CLINICAL PHARMACOLOGY Carisoprodol: Carisoprodol is a centrally-acting muscle relaxant that does not directly relax tense skeletal muscles in man. The mode of action of carisoprodol in relieving acute muscle spasm of local origin has not been clearly identified, but may be related to its sedative properties. In animals, carisoprodol has been shown to produce muscle relaxation by blocking interneuronal activity and depressing transmission of polysynaptic neurons in the spinal cord and in the descending reticular formation of the brain. The onset of action is rapid and lasts four to six hours. Carisoprodol is metabolized in the liver and is excreted by the kidneys. It is dialyzable by peritoneal and hemodialysis. Aspirin: Aspirin is a non-narcotic analgesic with anti-inflammatory and antipyretic activity. Inhibition of prostaglandin biosynthesis appears to account for most of its anti-inflammatory and for at least part of its analgesic and antipyretic properties. Aspirin is rapidly absorbed and almost totally hydrolyzed to salicylic acid following oral administration. Although aspirin has a half-life of only about 15 minutes, the apparent biologic half-life of salicylic acid in the therapeutic plasma concentration range is between 6 and 12 hours. Salicylic acid is eliminated by renal excretion and by biotransformation to inactive metabolites. Clearance of salicylic acid in the high-dose range is sensitive to urinary pH (see Drug Interactions ) and is reduced by renal dysfunction. Codeine Phosphate: Codeine phosphate is a centrally-acting narcotic-analgesic. Its actions are qualitatively similar to morphine, but its potency is substantially less. Clinical studies have shown that combining aspirin and codeine produces a significant additive effect in analgesic efficacy. INDICATIONS AND USAGE `Soma' Compound with Codeine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of pain, muscle spasm, and limited mobility associated with acute, painful musculoskeletal conditions when the additional action of codeine is desired. CONTRAINDICATIONS Acute intermittent porphyria; bleeding disorders; allergic or idiosyncratic reactions to carisoprodol, aspirin, codeine, or related compounds. WARNINGS On very rare occasions, the first dose of carisoprodol has been followed by idiosyncratic reactions, with symptoms appearing within minutes or hours. These may include extreme weakness, transient quadriplegia, dizziness, ataxia, temporary loss of vision, diplopia, mydriasis, dysarthria, agitation, euphoria, confusion, and disorientation. Although symptoms usually subside over the course of the next several hours, discontinue `Soma' Compound with Codeine and initiate appropriate supportive and symptomatic therapy, which may include epinephrine and/or antihistamines. In severe cases, corticosteroids may be necessary. Severe reactions have been manifested by asthmatic episodes, fever, weakness, dizziness, angioneurotic edema, smarting eyes, hypotension, and anaphylactoid shock. The effects of carisoprodol with agents such as alcohol, other CNS depressants, or psychotropic drugs may be additive. Appropriate caution should be exercised with patients who take one or more of these agents simultaneously with Soma Compound with Codeine. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS General: To avoid excessive accumulation of carisoprodol, aspirin, or their metabolites, use `Soma' Compound with Codeine with caution in patients with compromised liver or kidney function, or in elderly or debilitated patients (see CLINICAL PHARMACOLOGY ). Use with caution in patients with history of gastritis or peptic ulcer, in patients on anticoagulant therapy, and in addiction-prone individuals. Information for Patients: Caution patients that this drug may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a motor vehicle or operating machinery. Caution patients with a predisposition for gastrointestinal bleeding that concomitant use of aspirin and alcohol may have an additive effect in this regard. Caution patients that dosage of medications used for gout, arthritis, or diabetes may have to be adjusted when aspirin is administered or discontinued (see Drug Interactions ). Drug Interactions: Clinically important interactions may occur when certain drugs are administered concomitantly with aspirin or aspirin-containing drugs. Oral Anticoagulants -- By interfering with platelet function or decreasing plasma prothrombin concentration, aspirin enhances the potential for bleeding in patients on anticoagulants. Methotrexate -- aspirin enhances the toxic effects of this drug. Probenecid and Sulfinpyrazone -- large doses of aspirin reduce the uricosuric effect of both drugs. Renal excretion of salicylate may also be reduced. Oral Antidiabetic Drugs -- enhancement of hypoglycemia may occur. Antacids -- to the extent that they raise urinary pH, antacids may substantially decrease plasma salicylate concentrations; conversely, their withdrawal can result in a substantial increase. Ammonium Chloride -- this and other drugs that acidify a relatively alkaline urine can elevate plasma salicylate concentrations. Ethyl Alcohol -- enhanced aspirin-induced fecal blood loss has been reported. Corticosteroids -- salicylate plasma levels may be decreased when adrenal corticosteroids are given, and may be increased substantially when they are discontinued. Carcinogenesis, Mutagenesis, Impairment of Fertility: No long-term studies have been done with `Soma' Compound with Codeine. Pregnancy--Teratogenic Effects: Pregnancy Category C. Adequate animal reproduction studies have not been conducted with `Soma' Compound with Codeine. It is also not known whether `Soma' Compound with Codeine can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. `Soma' Compound with Codeine should be given to a pregnant woman only if clearly needed. Studies in rodents have shown salicylates to be teratogenic when given in early gestation, and embryocidal when given in later gestation in doses considerably greater than usual therapeutic doses in humans. Studies in women who took aspirin during pregnancy have not demonstrated an increased incidence of congenital abnormalities in the offspring. Labor and Delivery: Ingestion of aspirin near term or prior to delivery may prolong delivery or lead to bleeding in mother, fetus, or neonate. Nursing Mothers: Carisoprodol is excreted in human milk in concentrations two-to-four times that in maternal plasma. Aspirin is excreted in human milk in moderate amounts and can produce a bleeding tendency in nursing infants. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother. Pediatric Use: Safety and effectiveness in children below the age of twelve have not been established. ADVERSE REACTIONS If severe reactions occur, discontinue `Soma' Compound with Codeine and initiate appropriate symptomatic and supportive therapy. The following side effects which have occurred with the administration of the individual ingredients alone may also occur with the combination. Carisoprodol: Central Nervous System --Drowsiness is the most frequent complaint and along with other CNS effects may require dosage reduction. Observed less frequently are dizziness, vertigo and ataxia. Tremor, agitation, irritability, headache, depressive reactions, syncope, and insomnia have been infrequent or rare. Idiosyncratic --Idiosyncratic reactions are very rare. They are usually seen within the period of the first to fourth dose in patients having had no previous contact with the drug (see WARNINGS ). Allergic --Skin rash, erythema multiforme, pruritus, eosinophilia, and fixed drug eruptions with cross-reaction to meprobamate have been reported. If allergic reactions occur, discontinue `Soma' Compound with Codeine and treat symptomatically. In evaluating possible allergic reactions, also consider allergy to excipients (information on excipients is available to physicians on request). Cardiovascular --Tachycardia, postural hypotension, and facial flushing. Gastrointestinal --Nausea, vomiting, epigastric distress and hiccup. Hematologic --No serious blood dyscrasias have been attributed to carisoprodol alone. Leukopenia and pancytopenia have been reported, very rarely, in situations in which other drugs or viral infections may have been responsible. Aspirin: The most common adverse reactions associated with the use of aspirin have been gastrointestinal, including nausea, vomiting, gastritis, occult bleeding, constipation and diarrhea. Gastric erosion, angioedema, asthma, rash, pruritus and urticaria have been reported less commonly. Tinnitus is a sign of high serum salicylate levels (see OVERDOSAGE ). Aspirin Intolerance --Allergic type reactions in aspirin-sensitive individuals may involve the respiratory tract or the skin. Symptoms of the former range from rhinorrhea and shortness of breath to severe asthma, and the latter may consist of urticaria, edema, rash, or angioedema (giant hives). These may occur independently or in combination. Codeine Phosphate: Nausea, vomiting, constipation, miosis, sedation, and dizziness have been reported. DRUG ABUSE AND DEPENDENCE Controlled Substance: Schedule C-III (see PRECAUTIONS ). Abuse: In clinical use, abuse has been rare. Dependence: In clinical use, dependence with `Soma' Compound with Codeine has been rare and there have been no reports of significant abstinence signs. Nevertheless, the following information on the individual ingredients should be kept in mind. Carisoprodol --In dogs, no withdrawal symptoms occurred after abrupt cessation of carisoprodol from dosages as high as 1 gm/kg/day. In a study in man, abrupt cessation of 100 mg/kg/day (about five times the recommended daily adult dosage) was followed in some subjects by mild withdrawal symptoms such as abdominal cramps, insomnia, chills, headache, and nausea. Delirium and convulsions did not occur (see PRECAUTIONS ). Codeine Phosphate-- Drug dependence of the morphine type may result. OVERDOSAGE Signs and Symptoms: Any of the following which have been reported with the individual ingredients may occur and may be modified to a varying degree by the effects of the other ingredients present in `Soma' Compound with Codeine. Carisoprodol --Stupor, coma, shock, respiratory depression and, very rarely, death. Overdosage with carisoprodol in combination with alcohol, other CNS depressants, or psychotropic agents can have additive effects, even when one of the agents has been taken in the usually recommended dosage. Aspirin --Headache, tinnitus, hearing difficulty, dim vision, dizziness, lassitude, hyperpnea, rapid breathing, thirst, nausea, vomiting, sweating and occasionally diarrhea are characteristic of mild to moderate salicylate poisoning. Salicylate poisoning should be considered in children with symptoms of vomiting, hyperpnea, and hyperthermia. Hyperpnea is an early sign of salicylate poisoning, but dyspnea supervenes at plasma levels above 50 mg/dl. These respiratory changes eventually lead to serious acid-base disturbances. Metabolic acidosis is a constant finding in infants but occurs in older children only with severe poisoning; adults usually exhibit respiratory alkalosis initially and acidosis terminally. Other symptoms of severe salicylate poisoning include hyperthermia, dehydration, delirium, and mental disturbances. Skin eruptions, GI hemorrhage, or pulmonary edema are less common. Early CNS stimulation is replaced by increasing depression, stupor, and coma. Death is usually due to respiratory failure or cardiovascular collapse. Codeine Phosphate-- pinpoint pupils, CNS depression, coma, respiratory depression, and shock. Treatment: General --Provide symptomatic and supportive treatment, as indicated. Any drug remaining in the stomach should be removed using appropriate procedures and caution to protect the airway and prevent aspiration, especially in the stuporous or comatose patient. Incomplete gastric emptying with delayed absorption of carisoprodol has been reported as a cause for relapse. Should respiration or blood pressure become compromised, respiratory assistance, central nervous system stimulants, and pressor agents should be administered cautiously, as indicated. Carisoprodol --The following have been used successfully in overdosage with the related drug meprobamate: diuretics, osmotic (mannitol) diuresis, peritoneal dialysis, and hemodialysis (see CLINICAL PHARMACOLOGY ). Careful monitoring of urinary output is necessary and caution should be taken to avoid overhydration. Carisoprodol can be measured in biological fluid by gas chromatography (Douglas, J. F., et al: J Pharm Sci 58: 145, 1969). Aspirin --Since there are no specific antidotes for salicylate poisoning, the aim of treatment is to enhance elimination of salicylate and prevent or reduce further absorption; to correct any fluid, electrolyte or metabolic imbalance; and to provide general and cardiorespiratory support. If acidosis is present, intravenous sodium bicarbonate must be given, along with adequate hydration, until salicylate levels decrease to within the therapeutic range. To enhance elimination, forced diuresis and alkalinization of the urine may be beneficial. The need for hemoperfusion or hemodialysis is rare and should be used only when other measures have failed. Codeine Phosphate-- Narcotic antagonists, such as nalorphine and levallorphan, may be indicated. DOSAGE AND ADMINISTRATION Usual Adult Dosage: 1 or 2 tablets, four times daily. Not recommended for use in children under age twelve. HOW SUPPLIED `Soma' Compound with Codeine Tablets (carisoprodol, USP 200 mg, aspirin 325 mg, and codeine phosphate, USP 16 mg) are oval, convex, two-layered and inscribed on the white layer with SOMA CC and on the yellow layer with WALLACE 2403. The tablets are available in bottles of 100 (NDC 0037-2403-01). Welcome to the online pharmacy for Soma and Carisoprodol that you can trust. Through this website, you will be able to find all the information you need on Soma, Generic Soma, and Carisoprodol online. You can order Soma or Carisoprodol at the best prices online from the comfort of your own home. This website will allow you to avoid the problems of making an appointment with your Doctor just to get a prescription for soma. Our website allows you to order soma, or carisoprodol, with no prior prescription and have it delivered right to your office or home. No prior prescription needed No waiting rooms No appointments No consultation fees We offer discreet packaging and Overnight shipping Prescriptions filled by US-licensed pharmacies Prescriptions made only by US-licensed physicians If you are planning to buy Soma or Carisoprodol online, this is the right place for you. We offer the best prices for Soma and Carisoprodol you can find anywhere on the internet.

Soma (Sanskrit), or Haoma (Avestan), from Proto-Indo-Iranian *sauma-, was a ritual drink of importance among the early Indo-Iranians, and the later Vedic and greater Persian cultures. It is frequently mentioned in the Rigveda, which contains many hymns praising its energizing or intoxicating qualities. In the Avesta, Haoma has an entire Yasht dedicated to it. It is described as prepared by pressing juice from the stalks of a certain mountain plant, which has been variously hypothesized to be a psychedelic mushroom, cannabis, peganum harmala, or ephedra. In both Vedic and Zoroastrian tradition, the drink is identified with the plant, and also personified as a divinity, the three forming a religious or mythological unity. Contents [hide] 1 Etymology 2 Vedic Soma 2.1 In the Rigveda 2.2 In Hinduism 3 Avestan Haoma 4 Candidates for the Soma plant 5 References 6 External links [edit] Etymology Both Soma and the Avestan Haoma are derived from Proto-Indo-Iranian *sauma-. The name of the Scythian tribe Hauma-varga is related to the word, and probably connected with the ritual. The word is derived from an Indo-Iranian root *sav- (Sanskrit sav-) "to press", i.e. *sav-ma- is the drink prepared by pressing the stalks of a plant (cf. es-presso). The root is probably Proto-Indo-European (*sewh-), and also appears in son (from *suhnu-, "pressed out" i.e. "newly born"). [edit] Vedic Soma In the Vedas, Soma is portrayed as sacred and as a god (deva). The god, the drink and the plant probably referred to the same entity, or at least the differentiation was ambiguous. In this aspect, Soma is similar to the Greek ambrosia (cognate to amrita); it is what the gods drink, and what made them deities. Indra and Agni are portrayed as consuming Soma in copious quantities. The consumption of Soma by human beings, was probably under the belief that it bestowed them divine qualities. [edit] In the Rigveda The Rigveda (8.48.3, tr. Griffith) states, a apama somam amrta abhumaganma jyotir avidama devan c ki? nunam asman k??avad arati? kim u dhurtir am?ta martyasya We have drunk Soma and become immortal; we have attained the light, the Gods discovered. Now what may foeman's malice do to harm us? What, O Immortal, mortal man's deception? The Ninth Mandala of the Rigveda is known as the Soma Mandala. It consists entirely of hymns addressed to Soma Pavamana ("purified Soma"). The drink Soma was kept and distributed by the Gandharvas. The Rigveda associates the Sushoma, Arjikiya and other regions with Soma (e.g. 8.7.29; 8.64.10-11). Sharyanavat was possibly the name of a pond or lake on the banks of which Soma could be found. The plant is described as growing in the mountains (giristha, cf. Orestes), with long stalks, and of yellow or tawny (hari) colour. The drink is prepared by priests pounding the stalks with stones, an occupation that creates tapas (literally "heat", later referring to "spiritual excitement" in particular). The juice so gathered is mixed with other ingredients (including milk and honey) before it is drunk. Growing far away, in the mountains, Soma had to be purchased from travelling traders. This is connected with the Indo-Aryan migration model, i.e. the plant supposedly grew in the homeland of the Indo-Iranians, probably the Hindukush, but later migration to the Punjab removed them from the area of its occurrence, and it had to be imported. Later, knowledge of the plant was lost altogether, and Indian ritual reflects this, in expiatory prayers apologizing to the gods for the use of a substitute plant (e.g. rhubarb) because Soma had become unavailable. [edit] In Hinduism In Hindu art, the god Soma was depicted as a bull or bird, and sometimes as an embryo, but rarely as an adult human. In Hinduism, the god Soma evolved into a lunar deity, and became associated with the underworld. The moon is the cup from which the gods drink Soma, and so Soma became identified with the moon god Chandra. A waxing moon meant Soma was recreating himself, ready to be drunk again. Alternatively, Soma's twenty-seven wives were daughters of Daksha, who felt he paid too much attention to just one of his wives, Rohini. He cursed him to wither and die, but the wives intervened and the death became periodic and temporary, and is symbolized by the waxing and waning of the moon. The famous ayurvedic scholar Susruta wrote that the best Soma is found in the upper Indus and Kashmir region (Susruta Samhita: 537-538, SS.CS. 29.28-31). [edit] Avestan Haoma Main article: Haoma The continuing importance of Haoma in Zoroastrianism may be glimpsed from the Avesta (particularly in the Hom Yast, Yasna 9.11), and Avestan language *hauma also survived as middle Persian hom. The plant Haoma yielded the essential ingredient for the ritual drink, parahaoma. In the Hom yast of the Avesta, the Yazata (divine) Haoma appears to Zoroaster "at the time of pressing" (havani ratu) in the form of a beautiful man. Yasna 9.1 and 9.2 exhort him to gather and press Haoma plants. Haoma's epitheta include "the Golden-Green One" (zairi-, Sanskrit hari-), "righteous" (asavan-), "furthering righteousness" (asa-vazah-), and "of good wisdom" (hu.xratu-, Sanskrit sukratu-). In Yasna 9.22, Haoma grants "speed and strength to warriors, excellent and righteous sons to those giving birth, spiritual power and knowledge to those who apply themselves to the study of the nasks". As the religion's chief cult divinity he came to be perceived as its divine priest. In Yasna 9.26, Ahura Mazda is said to have invested him with the sacred girdle, and in Yasna 10.89, to have installed Haoma as the "swiftly sacrificing zaotar" (Sanskrit hotar) for himself and the Amesha Spenta. Haoma services were celebrated until the 1960s in a strongly conservative village near Yazd. [edit] Candidates for the Soma plant Main article: botanic identity of Soma-Haoma There has been much speculation as to the original Proto-Indo-Iranian Sauma plant. It was generally assumed to be hallucinogenic, based on RV 8.48 cited above. But note that this is the only evidence of hallucinogenic properties, in a book full of hymns to Soma. The typical description of Soma is associated with excitation and tapas. Soma is associated with the warrior-god Indra, and appears to have been drunk before battle. For these reasons, there are energizing plants as well as hallucinogenic plants among the candidates that have been suggested. In fact, several texts like the Atharva Veda extol the medicinal properties of Soma and he is regarded as the king of medicinal herbs (and also of the Brahmana class). Since the late 1700s, when Anquetil-Duperron and others made portions of the Avesta available to western scholarship, several scholars have sought a representative botanical equivalent of the haoma as described in the texts and as used in living Zoroastrian practice. Most of the proposals concentrated on either linguistic evidence or comparative pharmacology or reflected ritual use. Rarely were all three considered together, which usually resulted in such proposals being quickly rejected. In the late 19th century, the highly conservative Zoroastrians of Yazd (Iran) were found to use Ephedra (genus Ephedra), which was locally known as hum or homa and which they exported to the Indian Zoroastrians. (Aitchison, 1888) The plant, as Falk also established, requires a cool and dry climate, i.e. it does not grow in India (which is either too hot or too humid or both) but thrives in central Asia. Later, it was discovered that a number of Iranian languages and Persian dialects have hom or similar terms as the local name for some variant of Ephedra. Considered together, the linguistic and ritual evidence appeared to conclusively establish that haoma was some variant of Ephedra. [edit] References Jay, Mike: Blue Tide: The Search for Soma (Autonomedia 1999) Frawley David: The Rig Veda and the History of India, 2001.(Aditya Prakashan), ISBN 81-7742-039-9 Parpola, Asko, The problem of the Aryans and the Soma: Textual-linguistic and archaeological evidence, in: The Indo-Aryans of Ancient South Asia ed. G. Erdosy, de Gruyter (1995), 353–381. Nyberg, Harri, The problem of the Aryans and the Soma: The botanical evidence, in: The Indo-Aryans of Ancient South Asia ed. G. Erdosy, de Gruyter (1995), 382–406. Soma article from The Encyclopedia of Psychoactive Substances by Richard Rudgley Little, Brown and Company (1998) (huxley.net) PBS Secrets of the Dead. Day of the Zulu (pbs.org). Retrieved Feb. 5, 2005. Susruta Samhita. Transl. Kunjalal Bhishagratna, Varanasi: Chowkhama Sanksrit Series. 1981. Bakels, C.C. 2003. “The contents of ceramic vessels in the Bactria-Margiana Archaeological Complex, Turkmenistan.” Electronic Journal of Vedic Studies. Vol. 9. Issue 1c (May 5) http://users.primushost.com/~india/ejvs/ejvs0901/ejvs0901c.txt Swami Rama. Living with the Himalayan Masters. The Himalayan Institute Press. 1978. McDonald, A. A botanical perspective on the identity of soma (Nelumbo nucifera Gaertn.) based on scriptural and iconographic records. Econmic Botany 2004;58:S147-S173 Soma This page contains drug information on Soma. The information provided includes the following: what is Soma the possible side effects of Soma what happens if you miss a dose of Soma what happens if you overdose with Soma the most important information about Soma how to use Soma other drugs that may affect Soma what to avoid while using Soma Generic Name: carisoprodol (kar eye soe PROE dole) Brand Names: Soma, Vanadom What is the most important information I should know about carisoprodol? • Use caution when driving, operating machinery, or performing other hazardous activities. Carisoprodol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking carisoprodol. What is carisoprodol? • Carisoprodol is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. • Carisoprodol is used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. • Carisoprodol may also be used for purposes other than those listed in this medication guide. Who should not take carisoprodol? • Do not take carisoprodol if you have acute intermittent porphyria. • Before taking carisoprodol, tell your doctor if you have kidney or liver disease. You may need a lower dose or special monitoring during your therapy. • It is not known whether carisoprodol will harm an unborn baby. Do not take carisoprodol without first talking to your doctor if you are pregnant. • It is also not known whether carisoprodol passes into breast milk. Do not take carisoprodol without first talking to your doctor if you are breast-feeding a baby. • Carisoprodol is not approved for use in children younger than 12 years of age. How should I take carisoprodol? • Take carisoprodol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. • Take each dose with a full glass of water. • The maximum amount of carisoprodol you should take in one day is 1,400 mg (4 tablets). • Store carisoprodol at room temperature away from moisture and heat. What happens if I miss a dose? • Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication. Try to keep your doses at least 4 hours apart. What happens if I overdose? • Seek emergency medical attention. • Symptoms of a carisoprodol overdose include low blood pressure (weakness, fainting, confusion), decreased breathing, and unconsciousness. What should I avoid while taking carisoprodol? • Use caution when driving, operating machinery, or performing other hazardous activities. Carisoprodol may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking carisoprodol. What are the possible side effects of carisoprodol? • If you experience any of the following serious side effects, stop taking carisoprodol and seek emergency medical attention: · an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); · paralysis (loss of feeling) or extreme weakness; · vision loss; or · agitation or tremor. • Other, less serious side effects may be more likely to occur. Continue to take carisoprodol and talk to your doctor if you experience · drowsiness or dizziness; · headache; · depression; · blurred vision; · insomnia; or · hiccups. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. Soma Compound w/Codeine Tablets (carisoprodol, aspirin and codeine phosphate tablets, USP) carisoprodol 200 mg + aspirin 325 mg + codeine phosphate 16 mg--Warning: May be habit-forming TABLETS DESCRIPTION `Soma' Compound with Codeine is a combination product containing carisoprodol, a centrally-acting muscle relaxant, plus aspirin, an analgesic with antipyretic and anti-inflammatory properties and codeine phosphate, a centrally-acting narcotic analgesic. It is available as a two-layered, white and yellow, oval-shaped tablet for oral administration. Each tablet contains carisoprodol 200 mg, aspirin 325 mg, and codeine phosphate 16 mg. Chemically, carisoprodol is N-isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate. Its empirical formula is C 12 H 24 N 2 O 4 , with a molecular weight of 260.33. The structural formula is: Other ingredients: croscarmellose sodium, D&C Yellow #10, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, povidone, sodium metabisulfite, starch, stearic acid. CLINICAL PHARMACOLOGY Carisoprodol: Carisoprodol is a centrally-acting muscle relaxant that does not directly relax tense skeletal muscles in man. The mode of action of carisoprodol in relieving acute muscle spasm of local origin has not been clearly identified, but may be related to its sedative properties. In animals, carisoprodol has been shown to produce muscle relaxation by blocking interneuronal activity and depressing transmission of polysynaptic neurons in the spinal cord and in the descending reticular formation of the brain. The onset of action is rapid and lasts four to six hours. Carisoprodol is metabolized in the liver and is excreted by the kidneys. It is dialyzable by peritoneal and hemodialysis. Aspirin: Aspirin is a non-narcotic analgesic with anti-inflammatory and antipyretic activity. Inhibition of prostaglandin biosynthesis appears to account for most of its anti-inflammatory and for at least part of its analgesic and antipyretic properties. Aspirin is rapidly absorbed and almost totally hydrolyzed to salicylic acid following oral administration. Although aspirin has a half-life of only about 15 minutes, the apparent biologic half-life of salicylic acid in the therapeutic plasma concentration range is between 6 and 12 hours. Salicylic acid is eliminated by renal excretion and by biotransformation to inactive metabolites. Clearance of salicylic acid in the high-dose range is sensitive to urinary pH (see Drug Interactions ) and is reduced by renal dysfunction. Codeine Phosphate: Codeine phosphate is a centrally-acting narcotic-analgesic. Its actions are qualitatively similar to morphine, but its potency is substantially less. Clinical studies have shown that combining aspirin and codeine produces a significant additive effect in analgesic efficacy. INDICATIONS AND USAGE `Soma' Compound with Codeine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of pain, muscle spasm, and limited mobility associated with acute, painful musculoskeletal conditions when the additional action of codeine is desired. CONTRAINDICATIONS Acute intermittent porphyria; bleeding disorders; allergic or idiosyncratic reactions to carisoprodol, aspirin, codeine, or related compounds. WARNINGS On very rare occasions, the first dose of carisoprodol has been followed by idiosyncratic reactions, with symptoms appearing within minutes or hours. These may include extreme weakness, transient quadriplegia, dizziness, ataxia, temporary loss of vision, diplopia, mydriasis, dysarthria, agitation, euphoria, confusion, and disorientation. Although symptoms usually subside over the course of the next several hours, discontinue `Soma' Compound with Codeine and initiate appropriate supportive and symptomatic therapy, which may include epinephrine and/or antihistamines. In severe cases, corticosteroids may be necessary. Severe reactions have been manifested by asthmatic episodes, fever, weakness, dizziness, angioneurotic edema, smarting eyes, hypotension, and anaphylactoid shock. The effects of carisoprodol with agents such as alcohol, other CNS depressants, or psychotropic drugs may be additive. Appropriate caution should be exercised with patients who take one or more of these agents simultaneously with Soma Compound with Codeine. Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. PRECAUTIONS General: To avoid excessive accumulation of carisoprodol, aspirin, or their metabolites, use `Soma' Compound with Codeine with caution in patients with compromised liver or kidney function, or in elderly or debilitated patients (see CLINICAL PHARMACOLOGY ). Use with caution in patients with history of gastritis or peptic ulcer, in patients on anticoagulant therapy, and in addiction-prone individuals. Information for Patients: Caution patients that this drug may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a motor vehicle or operating machinery. Caution patients with a predisposition for gastrointestinal bleeding that concomitant use of aspirin and alcohol may have an additive effect in this regard. Caution patients that dosage of medications used for gout, arthritis, or diabetes may have to be adjusted when aspirin is administered or discontinued (see Drug Interactions ). Drug Interactions: Clinically important interactions may occur when certain drugs are administered concomitantly with aspirin or aspirin-containing drugs. Oral Anticoagulants -- By interfering with platelet function or decreasing plasma prothrombin concentration, aspirin enhances the potential for bleeding in patients on anticoagulants. Methotrexate -- aspirin enhances the toxic effects of this drug. Probenecid and Sulfinpyrazone -- large doses o